Andres Guardado has been ruled out of Mexico's World Cup qualifier against the United States on Feb. 11 in Ohio. Guardado's calf injury will take a minimum of six weeks to heal.
Guardado scored a goal against the US in the 2007 Gold Cup final and has become one of El Tri's best players.
The injury could open the door for Edgar Castillo to play against the Americans. Castillo is a capable left sided player but will have to earn a spot in the starting lineup.