Four Mexican teams will be in action on Wednesday and none of the results will count towards league play.
Chivas will play Everton in Copa Libertadores play in Mexico. Meanwhile Santos visits Montreal and Cruz Azul hosts Pumas in CONCACAF Champions League play.
In terms of results, Chivas' poor form could carry over into cup. Chivas need a victory over Everton as they need to maximize their home points. Chivas can ill afford to get a point and put themselves in position to get a road win or two just to advance. If they win, everything's fine in Copa. A draw or loss, and maybe the grumblings over Efrain Flores' job grow louder.
Meanwhile, Santos seems to be taking their Champions League effort seriously - at least that's what coach Daniel Guzman said.
This is in contrast to Pumas and Cruz Azul. However, Cruz Azul have six players out and suspended and will be forced to use backups.
Pumas, meanwhile, is fielding young players. They won't even bother to try and hide the fact that they are using only young players.. but given their horrendous league form, that may be a good thing.